DREAM Software is designed to manage, through a criterion of excellence, the centers for prevention and treatment of AIDS of the DREAM Program of the Community of Sant’Egidio, located in 10 African countries. The long experience in the field (since 2002) and the continuous investment in developing the software has allowed DREAMs to become a versatile tool for handling many patients and various chronic pathologies. Therefore it is not linked only to the HIV virus anymore, in view of the evolution of the DREAM Program in a global health program.